The project focuses on the role of glutamatergic neurotransmission in neuropsychiatric and neurodevelopmental diseases in clinical practice and experimental models. This direction of research has a long tradition at participating institutions and a high reputation on the international level. Its structure follows and qualitatively shifts previous successful centers (Center of Neuropsychiatric Studies, Center of Neuroscience) and at the same time develops results obtained in a number of grant projects. The concept is based on a translational approach to biomedical research. It focuses on the close interconnection of basic and clinical research aimed at improving knowledge of the causes and mechanisms of CNS disorders that will lead to improved diagnosis and selection of optimal therapeutic procedures.